Randomly ordered addressable high-density optical sensor arrays.

K L Michael; L C Taylor; S L Schultz; D R Walt

doi:10.1021/ac971343r

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PubMed · 9553489

Randomly ordered addressable high-density optical sensor arrays.

K L Michael·L C Taylor·S L Schultz·D R Walt

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Abstract

Array-based sensors provide an architecture for multianalyte sensing. In this paper, we report a new approach for array fabrication. Sensors are made by immobilizing different reactive chemistries on the surfaces of microspheres. Sensor arrays are prepared by randomly distributing a mixture of microsphere sensors on an optical substrate containing thousands of micrometer-scale wells. The sensors occupy a different location from array to array; thus the identity of each sensor is ascertained and registered on the detector using encoding schemes, rather than by a predetermined location in the array. The approach thereby shifts the demand from fabrication to signal processing. The availability of commercial image analysis software makes such a shift both cost-effective and time efficient.

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Cost-Benefit Analysis Fiber Optic Technology Fluorescent Dyes Microscopy, Atomic Force Microspheres Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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K L Michael, L C Taylor, S L Schultz, D R Walt. 1998-04-01. Randomly ordered addressable high-density optical sensor arrays.. https://doi.org/10.1021/ac971343r

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