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PubMed · 9530546

Cerivastatin.

K J McClellan·L R Wiseman·D McTavish
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Abstract

Cerivastatin is a synthetic HMG-CoA reductase inhibitor with high liver selectivity, which lowers plasma cholesterol levels by inhibiting endogenous cholesterol synthesis. In vitro, the affinity of cerivastatin for HMG-CoA reductase was higher than that of lovastatin, simvastatin and pravastatin. This higher enzyme affinity was reflected in vivo, with a lower ED50 (dose causing 50% inhibition) for cerivastatin in rats and beagle dogs compared with lovastatin. Cerivastatin 0.2 mg/day significantly reduced low density lipoprotein (LDL)-cholesterol, total cholesterol and triglyceride levels, and increased high density lipoprotein (HDL)-cholesterol levels, in patients with type IIa hypercholesterolaemia. Available data indicate that cerivastatin has a tolerability profile similar to that of other HMG-CoA reductase inhibitors. No drug interactions were observed when cerivastatin was coadministered with digoxin, warfarin, cimetidine or the antacid magnesium/aluminium hydroxide.

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AnimalsClinical Trials as TopicEnzyme InhibitorsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsPyridinesJournal ArticleReview

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K J McClellan, L R Wiseman, D McTavish. 1998. Cerivastatin.. https://doi.org/10.2165/00003495-199855030-00009

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