PubMed · 9433451
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A Marusić, N Kovacić, J Petrak. 1998-01-03. Presenting randomised trial reports.. https://doi.org/10.1016/s0140-6736(05)78049-1
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Accompanying changes in the way health services in Croatia are organised has been a significant change in the way the medical profession is regulated. In 1995 the Croatian Medical Chamber was established, with legal powers. The responsibilities of physicians to their patients are spelled out in considerable detail. Most of these responsibilities are matched by provisions in Croatia's criminal law. Croatia has about 10,000 doctors and dentists and since 1998 19 cases have been resolved by the Medical Chamber and its commissions. Public health providers offer protection in medical negligence cases but this could change as more market-oriented health-care provision is introduced. In 1997 and 1998 only 60 malpractice claims under the criminal law were brought and most of those were dismissed.
Medieval contracts for medical treatment are, without doubt, evidence of proper and adequate insight into the quality of operations performed centuries ago. Historical archives in Dalmatian cities have preserved a certain number of such contracts. Their contents assist in better understanding our historical heritage. This paper submits contracts, kept in Dubrovnik and Split, for the operation of inguinal hernia. A case depicting a defective palate treated by Amatus Lusitanus, who lived in Dubrovnik from 1555 to 1558, is also presented.
We describe for the first time extended haplotypes in a Croatian population. The present study gives the HLA-A, -B, -DRB1, -DQA1 and -DQB1 allele and haplotype frequencies in 105 families with at least two offspring. All individuals were studied by conventional serology for HLA class I antigens (A and B), while class II alleles (DRB1, DQA1, DQB1) were typed using the PCR-SSOP method. HLA genotyping was performed by segregation in all 105 families. For extended haplotype analysis, 420 independent parental haplotypes were included. Fourteen HLA-A, 18 HLA-B, 28 DRB1, 9 DQA1 and 11 DQB1 alleles were found in the studied population. Most of the DRB1 alleles in our population had an exclusive association with one specific DQA1-DQB1 combination. This strong linkage disequilibrium within the HLA class II region is often extended to the HLA-B locus. A total of 10 HLA-A, -B, -DRB1, -DQA1, -DQB1 haplotypes were observed with a frequency </= 1.0%. The three most frequent haplotypes were HLA-A1, B8, DRB1*0301, DQA1*0501, DQB1*0201; HLA-A3, B7, DRB1*1501, DQA1*0102, DQB1*0602 and HLA-A24, B44, DRB1*0701, DQA1*0201, DQB1*02. These results should provide a useful reference for further anthropological studies, transplantation studies, and studies of associations between HLA and diseases.