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PubMed · 9309146

[TNF].

N Yamauchi·Y Niitsu
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Abstract

TNF exerts its biological activities through two distinct receptors of TNF-R55 and TNF-R75. Recent studies have identified TNF receptor-associated molecules, and intracellular signal transduction for apoptosis induced by TNF has been elucidated. Various TNF mutants with higher affinity to TNF-R55 and lower affinity to TNF-R75 are being clarified biogenetically. These mutants show lower adverse effect and higher antitumor activity. Furthermore, TNF gene transduction into lymphocytes and tumor cells shows a decrease in tumorigenicity and enhancement of host immunogenicity. This approach appears to be promising for cancer treatment.

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AnimalsAntigens, CDAntineoplastic AgentsApoptosisHumansMiceMice, NudeNeoplasm TransplantationPancreatic NeoplasmsReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IISignal TransductionTumor Necrosis Factor-alphaEnglish AbstractJournal ArticleReview

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N Yamauchi, Y Niitsu. 1997. [TNF].. https://pubmed.ncbi.nlm.nih.gov/9309146/

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