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PubMed · 9285535

Pyrethroid decrease in central nervous system from nerve agent pretreatment.

B A Buchholz·N H Pawley·J S Vogel·R J Mauthe
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Abstract

We studied the effect of pyridostigmine bromide, a nerve agent prophylactic, on the central nervous system (CNS) uptake of [14C]permethrin, a pyrethroid insecticide, at scaled human-equivalent exposures in rats using accelerator mass spectrometry (AMS). AMS detects 14C at attomole sensitivities and determines the tissue distribution of 14C-labeled compounds. Pyridostigmine bromide in chow at 7.75 mg kg(-1) per day lowered the CNS tissue levels of permethrin, dosed at 4.75 microg kg(-1), in the CNS of rats by 30%. These results are inconsistent with hypothesized synergy of such compounds as a precursor to 'Gulf War syndrome'.

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AnimalsCarbon RadioisotopesCentral Nervous SystemCholinesterase InhibitorsInsecticidesMalePermethrinPyrethrinsPyridostigmine BromideRatsRats, Sprague-DawleyTissue DistributionJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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B A Buchholz, N H Pawley, J S Vogel, R J Mauthe. Pyrethroid decrease in central nervous system from nerve agent pretreatment.. https://doi.org/10.1002/(sici)1099-1263(199707)17%3A4%3C231%3A%3Aaid-jat434%3E3.0.co%3B2-j

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