[Endogenous digitalis-like factor].

M Yamazato; H Muratani; K Fukiyama

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PubMed · 9284409

[Endogenous digitalis-like factor].

M Yamazato·H Muratani·K Fukiyama

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Abstract

Evidence suggests the existence of a Na,K-ATPase inhibitor, so called endogenous digitalis-like factor (EDLF), in plasma. This substance has been postulated to enhance renal tubular sodium excretion and to increase peripheral vascular resistance. Recently, plant ouabain or its isomer (ouabain-like compound, OLC) was purified from human plasma and bovine hypothalamic extract. The OLC is considered to be a candidate for the EDLF. The OLC has been implicated in the pathogenesis of sodium-dependent hypertension. Furthermore, accumulating evidence suggests central nervous system as a site of hypertensinogenic action of OLC.

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Animals Biological Factors Cardenolides Cattle Central Nervous System Digoxin Humans Hypertension Saponins Sodium-Potassium-Exchanging ATPase Journal Article Review

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M Yamazato, H Muratani, K Fukiyama. 1997. [Endogenous digitalis-like factor].. https://pubmed.ncbi.nlm.nih.gov/9284409/

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