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PubMed · 9261803

Fear decrease in transgenic mice overexpressing bcl-2 in neurons.

L Rondi-Reig·Y Lemaigre Dubreuil·J C Martinou·N Delhaye-Bouchaud·J Caston·J Mariani
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Abstract

Neuronal destruction in the amygdala, hypothalamus and cerebellum provokes a diminution in anxiety and neophobia. In transgenic mice that express the human bcl-2 gene under the control of neuron specific enolase promotor (Hu-bcl-2), BCL-2 overexpression reduces the naturally occurring neuronal death, producing an increase of the number of neurons and brain size. Since BCL-2 over-expression has been observed in different parts of the brain and especially in the amygdaloid nuclei, the hypothalamus and the cerebellum, we studied the fear-related behavior of these transgenic mice. Hu-bcl-2 transgenic mice showed a decrease in anxiety and neophobia, indicating that, for this particular behavior, supernumerary neurons elicit the same modification as that observed after neuronal destruction.

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AnimalsExploratory BehaviorFearHumansMaze LearningMiceMice, TransgenicNeuronsPhosphopyruvate HydratasePromoter Regions, GeneticProto-Oncogene Proteins c-bcl-2Recombinant ProteinsComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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L Rondi-Reig, Y Lemaigre Dubreuil, J C Martinou, N Delhaye-Bouchaud, J Caston, J Mariani. 1997-07-28. Fear decrease in transgenic mice overexpressing bcl-2 in neurons.. https://doi.org/10.1097/00001756-199707280-00004

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