Observations on memory B-cell development.

D Gray; S Bergthorsdottir; D van Essen; M Wykes; J Poudrier; K Siepmann

doi:10.1006/smim.1997.0077

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Observations on memory B-cell development.

D Gray·S Bergthorsdottir·D van Essen·M Wykes·J Poudrier·K Siepmann

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Abstract

We dissect in this article the roles of CD40 and its ligand in memory B-cell formation. Our data indicate that CD40 ligation does not directly lead to GC formation but it plays an indirect role related to maturation of helper T cells; signalling is bidirectional, to B cells, via CD40, upregulating cytokine receptor expression and to T cells, via CD40L, causing secretion of cytokines necessary for GC initiation. Later in the GC, CD40 selects mutated B cells for entry into the memory pool. This second T-cell-mediated CD40 ligation has consequences distinct from the first (rescue versus proliferation) that arise from rewiring of CD40 signal transduction pathways.

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Animals B-Lymphocytes CD40 Antigens CD40 Ligand Cell Differentiation Germinal Center Humans Immunologic Memory Membrane Glycoproteins Plasma Cells Signal Transduction T-Lymphocytes, Helper-Inducer Journal Article Research Support, Non-U.S. Gov't Review

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D Gray, S Bergthorsdottir, D van Essen, M Wykes, J Poudrier, K Siepmann. 1997. Observations on memory B-cell development.. https://doi.org/10.1006/smim.1997.0077

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