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PubMed · 9237272

Transient decrease of HPC-1/syntaxin-1A mRNA in the rat hippocampus by kainic acid.

I Fujino·T Fujiwara·K Akagawa
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Abstract

HPC-1/syntaxin-1A is a neuronal protein of which the mRNA has an immediate early gene-like structure in its 3'-untranslated region. Whereas HPC-1/syntaxin-1A protein plays a crucial role in neurotransmitter release, little is known about HPC-1 gene expression. We demonstrate here that HPC-1 mRNA expression in rat hippocampal neurons in vivo decreased 8 h after kainic acid (KA) administration, but was restored thereafter. The transient decrease of HPC-1 mRNA upon KA administration suggests that the HPC-1 mRNA expression in neurons could be altered by excitation by trans-synaptic stimulation.

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AnimalsAntigens, SurfaceBlotting, SouthernDepression, ChemicalExcitatory Amino Acid AgonistsFemaleHippocampusIn Situ HybridizationInjections, IntraperitonealKainic AcidNerve Tissue ProteinsPolymerase Chain ReactionRNA, MessengerRatsRats, WistarSyntaxin 1Journal ArticleResearch Support, Non-U.S. Gov't

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I Fujino, T Fujiwara, K Akagawa. 1997. Transient decrease of HPC-1/syntaxin-1A mRNA in the rat hippocampus by kainic acid.. https://doi.org/10.1016/s0168-0102(97)00050-3

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