Methadone and brain development.

I S Zagon; P J McLaughlin

doi:10.1007/bf01918824

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Methadone and brain development.

I S Zagon·P J McLaughlin

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Abstract

The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of offspring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%, respectively), and DNA values (50% and 34%, respectively) observed.

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Animals Brain Brain Chemistry DNA Female Gestational Age Lactation Maternal-Fetal Exchange Methadone Organ Size Pregnancy Rats Journal Article

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I S Zagon, P J McLaughlin. 1977-11-15. Methadone and brain development.. https://doi.org/10.1007/bf01918824

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