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PubMed · 9181133

[Cholesterol and development].

C Roux·C Wolf·B Llirbat·M Kolf·N Mulliez·J L Taillemite·V Cormier·M Le Merrer·F Chevy·D Citadelle
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Abstract

The teratogenic action of distal inhibitors of cholesterol synthesis has been known for some time. The induced malformations are of a particular type: they include holoprosencephalies. Recently these observations have solicited increased interest due to: 1/ the discovery in 1993 of a similar form of inhibition of cholesterol synthesis which is responsible for a human malformation syndrome, Smith-Lemli-Opitz; 2/ the demonstration of the involvement of the Sonic Hedgehog gene in normal development of prosencephalon and the description of the mode of action of the protein Shh: autoprocessing followed by "cholesterolisation".

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AnimalsAnticholesteremic AgentsCholesterolEmbryonic and Fetal DevelopmentGenesHoloprosencephalyIn Vitro TechniquesMiceRatstrans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane DihydrochlorideEnglish AbstractJournal ArticleReview

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C Roux, C Wolf, B Llirbat, M Kolf, N Mulliez, J L Taillemite, V Cormier, M Le Merrer, F Chevy, D Citadelle. 1997. [Cholesterol and development].. https://pubmed.ncbi.nlm.nih.gov/9181133/

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