Interferon expression by B cells.

H A Young

doi:10.1006/meth.1996.0394

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PubMed · 8990096

Interferon expression by B cells.

H A Young

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Abstract

Interferons have effects on many facets of immune system development, maturation, and function. B cells are a target for the interferons, causing alterations in cell differentiation and gene expression. However, production of interferons by B cells has not been widely studied. In this review I will discuss the limited literature on B-cell interferon production. In addition I will describe results obtained from a transgenic model in which interferon-gamma production has been targeted to the B-cell compartment. In this animal, B-cell development is blocked, reflecting the deleterious effects that aberrant expression of interferon can have on this cell population.

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Animals B-Lymphocytes Blotting, Southern Bone Marrow Gene Expression Regulation Interferon-alpha Interferon-gamma Interferons Mice Mice, Transgenic RNA, Messenger Journal Article

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H A Young. 1997. Interferon expression by B cells.. https://doi.org/10.1006/meth.1996.0394

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