Hypertonic-hyperoncotic solution increases canine lymph flows.

C J Wickerts; B Berg; H Blomqvist

doi:10.1111/j.1399-6576.1996.tb04398.x

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Hypertonic-hyperoncotic solution increases canine lymph flows.

C J Wickerts·B Berg·H Blomqvist

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Abstract

BACKGROUND: Hypertonic-hyperoncotic solutions (HHS) have attracted a lot of interest in the treatment of various forms of hypovolaemic conditions during the last decade. It has been speculated that HHS might even be of therapeutic value in normo- and hypervolaemic conditions by mobilising extravascular fluid. METHODS: We studied thoracic and abdominal lymphatic flows and circulatory response following the administration of a single bolus injection of hypertonic-hyperoncotic solution, 10% dextran 60 in 7.2% saline (HHS), in a nonhypovolaemic canine model. A modified surgical procedure for collecting thoracic lymph is also presented. RESULTS: Both thoracic and abdominal lymph flow increased significantly by approximately 50% after administration of HHS. Cardiac output and calculated pulmonary capillary hydrostatic pressure increased. CONCLUSION: Hypertonic-hyperoncotic solution given intravenously as a single injection increased both thoracic and abdominal lymph flows in the initially normovolaemic animal.

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Animals Dogs Female Hypertonic Solutions Lymph Male Journal Article Research Support, Non-U.S. Gov't

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C J Wickerts, B Berg, H Blomqvist. 1996. Hypertonic-hyperoncotic solution increases canine lymph flows.. https://doi.org/10.1111/j.1399-6576.1996.tb04398.x

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