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PubMed · 8873132

Decrease in exploratory behavior in naturally occurring cholecystokinin (CCK)-A receptor gene knockout rats.

S Kobayashi·M Ohta·K Miyasaka·A Funakoshi
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Abstract

We recently found a specific strain of rats (Otsuka Long Evans Tokushima Fatty; OLETF rats) lacking cholecystokinin (CCK)-A receptor because of a genetic abnormality. Since CCK is an abundant neurotransmitter peptide in the brain, we examined whether these animals exhibit any behavioral abnormalities by conducting open-field tests. OLETF rats showed hypolocomotor activity and a decrease in the incidence of rearing in open-field tests. CCK release from the synaptosomes, and levels of CCK and CCK-B receptor mRNAs were the same as those observed in normal rats. It is suggested that the decreased exploration in OLETF rats may be due to the lack of CCK-A receptor.

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AnimalsBehavior, AnimalExploratory BehaviorGroomingHormone AntagonistsMaleMotor ActivityMutationProglumideRatsRats, Inbred StrainsRats, Mutant StrainsReceptor, Cholecystokinin AReceptors, CholecystokininReference ValuesJournal ArticleResearch Support, Non-U.S. Gov't

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S Kobayashi, M Ohta, K Miyasaka, A Funakoshi. 1996-08-16. Decrease in exploratory behavior in naturally occurring cholecystokinin (CCK)-A receptor gene knockout rats.. https://doi.org/10.1016/0304-3940(96)12881-0

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