Autoimmune myocarditis.

N R Rose; S L Hill

doi:10.1016/0167-5273(96)02595-8

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PubMed · 8803682

Autoimmune myocarditis.

N R Rose·S L Hill

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Abstract

We have developed two models of myocarditis in mice. The first is produced by infection with Coxsackievirus B3; the second results from immunization with cardiac myosin. Both forms of myocarditis occur in the same genetically predisposed strains. Genetically resistant mice can be rendered susceptible to myocarditis by co-treatment with cytokines IL-1 or TNF. Moreover, the disease is inhibited by administration of an antagonist of IL-1. These models will be useful for clarifying outstanding issues related to human myocarditis or dilated cardiomyopathy.

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Animals Autoimmunity Disease Models, Animal Enterovirus B, Human Mice Myocarditis Myosins Journal Article Research Support, U.S. Gov't, P.H.S.Review

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N R Rose, S L Hill. 1996. Autoimmune myocarditis.. https://doi.org/10.1016/0167-5273(96)02595-8

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