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PubMed · 8646917

[Xenotransplantation].

D J White·R Y Calne
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Abstract

This paper describes the rationale behind the need for xenotransplantation and the physiological and immunological barriers associated with xenografting from pig to man. The scientific strategies developed for overcoming the immunological barriers associated with hyperacute rejection are described in detail as is the technology for producing transgenic pigs. Data on perfusion studies of transgenic pig hearts with human blood demonstrates the validity of this scientific approach.

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AnimalsAnimals, Genetically ModifiedCD55 AntigensComplement ActivationFemaleGraft RejectionHeart TransplantationHumansMalePerfusionSwineTransplantation, HeterologousJournal ArticleReview

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D J White, R Y Calne. 1996. [Xenotransplantation].. https://pubmed.ncbi.nlm.nih.gov/8646917/

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