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PubMed · 8525076

Experimental megaileum.

S B Garcia·L Z Pinto·S Zucoloto·J S Oliveira
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Abstract

Typical megaileum occurred in young male Wistar rats three months after ileum myenteric plexus denervation. An average of 58.4% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in an 8 nm ring-shaped histological sectfrom the midportion of the treated segment. A morphometric study showed that the increased thickness of the megaileum wall was due to muscle hypertrophy and mucosal hyperplasia. The potential usefulness of this model of megaileum is emphasized.

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AnimalsBenzalkonium CompoundsDenervationHyperplasiaHypertrophyIleal DiseasesIntestinal MucosaMaleMuscle, SmoothMyenteric PlexusRatsRats, WistarJournal ArticleResearch Support, Non-U.S. Gov't

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S B Garcia, L Z Pinto, S Zucoloto, J S Oliveira. 1995. Experimental megaileum.. https://doi.org/10.1007/bf02576795

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