Dynamic concentration challenges for biosensor characterization.

D A Baker; D A Gough

doi:10.1016/0956-5663(93)80028-n

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Dynamic concentration challenges for biosensor characterization.

D A Baker·D A Gough

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Abstract

A method and apparatus are described for characterization of the steady state and dynamic response of biosensors. The apparatus produces a steady stream of homogeneously mixed analyte whose concentration can be fixed at discrete values or varied continuously. The device is ideally suited for continuously operated biosensors, but is also effective for biosensors that operate in discrete sampling modes. The system permits simultaneous testing of several sensors and determination of the accuracy, precision and repeatability of sensor response. The characteristics of this testing apparatus were validated with ferrocyanide and glucose as indicators. As an example of use of the apparatus, concentration ramps were created and used to complement conventional step changes for characterizing an implantable glucose sensor. The ramp rate can be adjusted easily by scaling the apparatus to simulate the rate of concentration change anticipated during actual monitoring situations.

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Animals Biosensing Techniques Electronics, Medical Evaluation Studies as Topic Glucose Humans Monitoring, Physiologic Journal Article Research Support, U.S. Gov't, P.H.S.

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D A Baker, D A Gough. 1993. Dynamic concentration challenges for biosensor characterization.. https://doi.org/10.1016/0956-5663(93)80028-n

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