Thymic selection reinterpreted.

J I Elliot

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PubMed · 8282315

Thymic selection reinterpreted.

J I Elliot

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Abstract

To summarize, I have attempted to present evidence that the unselected thymocyte TCR repertoire has such a propensity to recognize MHC/peptide at high affinity that it is likely that, were tolerance induction to be invariably dominant over positive selection, all T cells would be deleted or anergized. If this is true it follows that positive selection must in fact be capable of being the dominant process. I have further suggested that the existence of peptides capable of antagonizing T-cell activation in the thymus could inhibit deletion, and that this might correspond to positive selection.

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Animals H-Y Antigen Humans Major Histocompatibility Complex Models, Biological Peptide Fragments Self Tolerance T-Lymphocytes Thymus Gland Journal Article Research Support, Non-U.S. Gov't Review

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J I Elliot. 1993. Thymic selection reinterpreted.. https://pubmed.ncbi.nlm.nih.gov/8282315/

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