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PubMed · 8216210

Decrease in cerebral inositols in rats and humans.

R A Moats·Y H Lien·D Filippi·B D Ross
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Abstract

Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain. The portacaval-shunted rat may therefore be a useful model for the investigation of neurochemical pathways containing myoinositol, which are modulated not only in hepatic encephalopathy but also in diabetes mellitus and Alzheimer's disease.

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AnimalsBrain ChemistryDisease Models, AnimalHepatic EncephalopathyHumansInositolMagnetic Resonance SpectroscopyMalePortacaval Shunt, SurgicalRatsRats, Sprague-DawleyComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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R A Moats, Y H Lien, D Filippi, B D Ross. 1993-10-01. Decrease in cerebral inositols in rats and humans.. https://doi.org/10.1042/bj2950015

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