T-cell development and function in gene-knockout mice.

R S Yeung; J Penninger; T W Mak

doi:10.1016/0952-7915(94)90105-8

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T-cell development and function in gene-knockout mice.

R S Yeung·J Penninger·T W Mak

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Abstract

The use of mice with defined genetic defects engineered by homologous recombination in embryonic stem cells has greatly enhanced our understanding of immune functions at the single-gene level. The complex molecular interactions involved in T-cell development and antigen recognition have been especially targeted for detailed analysis via knockout technology.

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Animals Antigens, CD Cell Differentiation Cytokines Mice Mice, Knockout Receptor-CD3 Complex, Antigen, T-Cell Signal Transduction T-Lymphocytes Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't Review

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R S Yeung, J Penninger, T W Mak. 1994. T-cell development and function in gene-knockout mice.. https://doi.org/10.1016/0952-7915(94)90105-8

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