Multiple osteomas in mice.

H Höger; J Gialamas; F Jelinek

doi:10.1177/030098589403100404

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Multiple osteomas in mice.

H Höger·J Gialamas·F Jelinek

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Abstract

Osteomas (dense compact neoplasms of mature bone tissue) are rare in nearly all strains and stocks of mice. Of 224 Him:OF1 mice maintained until natural death or until terminally ill, 116 (51.8%) had one or more osteomas. Osteomas had a predilection for the skull and the larger bones of the limbs. Plasma alkaline phosphatase concentrations were elevated significantly in osteoma-bearing mice (446 +/- 153 U/liter versus 206 +/- 65 U/liter in age-matched controls without osteomas). Only very large osteomas resulted in clinical signs, and longevity was not shortened. Histologic examination showed clearly separated dense bony tissue irregularly arranged and forming a mosaic pattern, with distinct cement lines and medullary spaces filled with fibroreticular connective tissue. Electron microscopic examination revealed virus-like structures in osteoblasts, osteocytes, and fibroblasts and in the place of remnants of necrotic cells.

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Animals Bone Neoplasms Bone and Bones Female Male Mice Microscopy, Electron Osteoma Rodent Diseases Journal Article

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H Höger, J Gialamas, F Jelinek. 1994. Multiple osteomas in mice.. https://doi.org/10.1177/030098589403100404

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