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PubMed · 7935029

Androgenic progestogens oppose the decrease of insulin-like growth factor I serum level induced by conjugated oestrogens in postmenopausal women. Preliminary report.

C Campagnoli·N Biglia·M G Lanza·L Lesca·C Peris·P Sismondi
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Abstract

Oral oestrogen treatment in postmenopausal women causes a decrease of insulin-like growth factor I (IGF-I) serum level, probably through a hepatocellular effect. To explore the possibility that the androgenic progestogens oppose this effect, serum IGF-I and sex hormone binding globulin (SHBG) were evaluated in two groups of patients treated respectively with oral conjugated oestrogens (oCE) or transdermal oestradiol (tdE2), in a first phase with the addition of dydrogesterone (DYDR), a non-androgenic progestogen, and subsequently with the addition of norethisterone acetate (NETA). With respect to basal values, treatment with oCE+DYDR caused an increase of SHBG (P < 0.002) and a decrease of IGF-I serum levels (P < 0.05); the shift to NETA addition opposed both effects: SHBG levels decreased partially but significantly (P < 0.01 vs. oCE + DYDR) and IGF-I returned to basal values with a significant increase with respect to the oCE + DYDR phase (P < 0.02). No changes were observed in the tdE2 + DYDR treated women; in this group the shift to NETA addition caused a significant decrease of SHBG values (P < 0.001 vs. before treatment and vs. tdE2 + DYDR phase) and a slight increase of IGF-I values. These differential effects on IGF-I and SHBG serum levels might be relevant as far as breast cancer risk is concerned.

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Administration, CutaneousAdministration, OralAdultBreast NeoplasmsClimactericDrug Therapy, CombinationDydrogesteroneEstradiolEstrogen Replacement TherapyEstrogens, Conjugated (USP)FemaleHumansInsulin-Like Growth Factor IMiddle AgedNorethindroneNorethindrone AcetateRisk FactorsSex Hormone-Binding GlobulinClinical TrialControlled Clinical TrialJournal Article

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C Campagnoli, N Biglia, M G Lanza, L Lesca, C Peris, P Sismondi. 1994. Androgenic progestogens oppose the decrease of insulin-like growth factor I serum level induced by conjugated oestrogens in postmenopausal women. Preliminary report.. https://doi.org/10.1016/0378-5122(94)90038-8

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