[Particle state: divided solids and functionality].

Abstract

Physical and physico-mechanical properties of powder particles, in the field of pharmacy, as drugs, excipients, microparticles and so on... are one of the main element in quality of dosage forms. The aim of this work is to insist on the importance of packing and rheological properties of divided solids and on his influence on compacting behaviour in drug development and industrial process, to avoid difficulties due to the variability of physical properties batch to batch. But as the physical quality of material raw is induced up to the crystallization operation, it is necessary to know, before, what use it will be done.