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Biomedical subjects

Y Pourcelot

Publications and source records attributed to Y Pourcelot.

5 recordsLinked to original sources
PubMed1999

Preformulation: effect of moisture content on microcrystalline cellulose (Avicel PH-302) and its consequences on packing performances.

This study evaluates the influence of moisture content on the packing performances of a new grade of microcrystalline cellulose (MCC) (Avicel PH-302) either by classical method or by an unconventional compression technique (constant volume reduction of powder bed). An increase in moisture content decreases the apparent density of the powder bed, resulting from interparticulate friction enhancement. This modification of apparent density seems to be the main effect caused by the presence of humidity, which explains the variations of compression properties, like an increase of powder plasticity generally observed in the experimental conditions.

Cellulose↗
PubMed1996

Study of morphology of reactive dissolution interface using fractal geometry.

The determination of reactive fractal dimension was carried out using two forms of the Noyes-Whitney equation, -dQ/dt = K(Q/Q0)DR/3 and -dQ/dt = K'RDR-3 using the Richardson plot on the basis of previous data obtained by dissolution of an orthoboric acid powder. The correlation of the results provided by the two ways of calculation allows proposal of the hypothesis that dissolution begins on a specific population of reactive sites and probably promotes the formation of microporous volumes or cracks.

Microscopy, Electron, Scanning↗
PubMed1994

[Particle state: divided solids and functionality].

Physical and physico-mechanical properties of powder particles, in the field of pharmacy, as drugs, excipients, microparticles and so on... are one of the main element in quality of dosage forms. The aim of this work is to insist on the importance of packing and rheological properties of divided solids and on his influence on compacting behaviour in drug development and industrial process, to avoid difficulties due to the variability of physical properties batch to batch. But as the physical quality of material raw is induced up to the crystallization operation, it is necessary to know, before, what use it will be done.

Elementary Particles↗