PubMed · 7695722
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Z Blumenfeld. 1994. Long live the small difference.. https://doi.org/10.1016/0002-9378(94)90420-0
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In conclusion, combined administration of 17beta-estradiol and vitamin E protects LDL in postmenopausal women from oxidation with no synergism noted compared with either therapy given alone.
Two female patients with acute intermittent porphyria, who received oestrogen skin pads as supplementary treatment for postmenopausal discomfort, developed severe psychiatric disorders with persistent confusion, aggression and paranoid reactions. Some decades earlier they had reacted with symptoms of acute porphyria following oral contraceptive usage. There is well documented evidence of the advisability of restrictiveness in the use of oestrogens in conjunction with acute porphyria, particularly in cases of patients with a history of hormone-related symptoms of acute porphyria. The putative mechanisms by means of which oestrogens may exert effects on neurotransmitters and peptides are discussed in the article. The authors would be grateful to hear from colleagues abroad who have treated patients with similar symptoms following postmenopausal treatment with oestrogens.
In 1973, the histopathologic features of nine neoplasms with a distinctive appearance were reported under the term "female adnexal tumor of probable Wolffian origin." Although to date more than 40 cases of this disease have been reported in the literature, there have been only a few reports that the tumors might be endocrinologically active. We report on a hormonally active tumor of this type.