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PubMed · 7580140

Vertebrate limb development.

C Tickle
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Abstract

The recent identification of Wnt-7a as a signalling molecule in dorsal/ventral patterning means that we now have a known signal for control of each of the three limb axes. Fibroblast growth factors can allow proximal/distal patterning and Sonic hedgehog gene expression signals anterior/posterior patterning. Networks of these signals not only coordinate cell responses, but also mutually maintain each other. A positive feedback loop is established which coordinates expression of Sonic hedgehog in mesenchyme cells of the polarizing region and Fgf-4 expression in overlying apical ridge ectoderm. Wnt-7a expression in dorsal ectoderm also influences Sonic hedgehog expression in the polarizing region. Initiation of development of a complete limb can be achieved with just one signal, a growth factor.

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AnimalsEmbryonic InductionExtremitiesGene Expression Regulation, DevelopmentalHedgehog ProteinsLimb BudsProteinsSignal TransductionTrans-ActivatorsVertebratesJournal ArticleReview

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C Tickle. 1995. Vertebrate limb development.. https://doi.org/10.1016/0959-437x(95)90052-i

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