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Poly(ADP-ribose) polymerase: structure-function relationship.

M Masson·V Rolli·F Dantzer·C Trucco·V Schreiber·S Fribourg·M Molinete·A Ruf·E A Miranda·C Niedergang
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Abstract

Dissection of the human poly(ADP-ribose) polymerase (PARP) molecule in terms of its structure-function relationship has proved to be an essential step towards understanding the biological role of poly(ADP-ribosylation) as a cellular response to DNA damage in eukaryotes. Current approaches aimed at elucidating the implication of this multifunctional enzyme in the maintenance of the genomic integrity will be presented.

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AnimalsCatalysisChickensCrystallizationCrystallography, X-RayDNA DamageDNA RepairDNA-Binding ProteinsGenome, HumanHeLa CellsHumansPoly(ADP-ribose) PolymerasesProtein Structure, TertiaryRecombinant ProteinsStructure-Activity RelationshipTransfectionJournal ArticleResearch Support, Non-U.S. Gov't

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M Masson, V Rolli, F Dantzer, C Trucco, V Schreiber, S Fribourg, M Molinete, A Ruf, E A Miranda, C Niedergang. 1995. Poly(ADP-ribose) polymerase: structure-function relationship.. https://doi.org/10.1016/0300-9084(96)88160-0

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