Neuronal Ca2+ stores: activation and function.

P B Simpson; R A Challiss; S R Nahorski

doi:10.1016/0166-2236(95)93919-o

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Neuronal Ca2+ stores: activation and function.

P B Simpson·R A Challiss·S R Nahorski

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Abstract

The intracellular concentration of free Ca2+ ([Ca2+]i) displays complex fluctuations in response to a variety of stimuli, and acts as a pluripotent signal for many neuronal functions. It is well established that various 'metabotropic' neurotransmitter receptors can mediate the mobilization of Ca2+ stores via actions of inositol-polyphosphate second messengers, and more recent evidence suggests that 'ionotropic' receptor-mediated Ca2+ signals in neurones might also involve release of Ca2+ from intracellular stores. These two mechanisms of release of Ca2+ enable considerable temporal and spatial complexity of increases in the [Ca2+]i via multiple interactions at the level of intracellular-receptor activation. The complexity of Ca2+ signalling that is elicited via these interconnecting pathways might underlie mechanisms that are central to information transfer and integration within neuronal compartments.

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Animals Biotransformation Calcium Humans Neurons Journal Article Research Support, Non-U.S. Gov't Review

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P B Simpson, R A Challiss, S R Nahorski. 1995. Neuronal Ca2+ stores: activation and function.. https://doi.org/10.1016/0166-2236(95)93919-o

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