Vitamin E: beyond antioxidant function.

M G Traber; L Packer

doi:10.1093/ajcn/62.6.1501s

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Vitamin E: beyond antioxidant function.

M G Traber·L Packer

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Abstract

Vitamin E, a potent peroxyl radical scavenger, is a chain-breaking antioxidant that prevents the propagation of free radical damage in biological membranes. We consider the evidence for potential sites in cellular metabolism and signal transduction where vitamin E may have a structure-specific role in addition to its antioxidant function. The roles of tocopherol-binding proteins in cellular trafficking of vitamin E, especially the incorporation of RRR-alpha-tocopherol into nascent lipoproteins, and the delivery of RRR-alpha-tocopherol to the nucleus are considered. We discuss the functions of vitamin E both in the inhibition and potentiation of arachidonic acid metabolism. The interactions of vitamin E during cell proliferation and differentiation are also evaluated. These functions of vitamin E raise new questions and represent new and exciting areas for research in cell regulation with physiologic implications.

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Animals Antioxidants Arachidonic Acid Carrier Proteins Cell Division Humans NF-kappa B Protein Kinase C Vitamin E Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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M G Traber, L Packer. 1995. Vitamin E: beyond antioxidant function.. https://doi.org/10.1093/ajcn%2F62.6.1501s

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