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PubMed · 746456

Breast reduction.

B M de Saxe
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Abstract

Large breasts cause problems mainly because of physical discomfort and/or associated emotional problems, and surgery is sought primarily for these rather than for purely cosmetic reasons. Indications for carrying out a breast reduction are given, and important questions are posed and answered to help elucidate many of the factors pertaining to the operation. The overall results that can be expected as well as the possible complications are discussed. A table listing complications in a series of 50 patients is shown. In conclusion, the degree of patient satisfaction that can be expected is briefly discussed.

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BreastFemaleHumansSurgery, PlasticJournal Article

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BibTeXRIS

B M de Saxe. 1978-12-16. Breast reduction.. https://pubmed.ncbi.nlm.nih.gov/746456/

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Interaction of gangliosides with the methyltransferase-I of microsomes from normal and neoplastic human mammary gland.

The activity of the phospholipid methyltransferase-I, which catalyzes the rapid transmethylation of phosphatidylethanolamine to phosphatidylcholine, was found to be about 6-fold enhanced in microsomal membranes of breast cancer with respect to the level found in normal human mammary gland. Exogenous gangliosides GM1 and GM2 added to neoplastic breast microsomes induced progressive inhibition of the methyltransferase activity. In contrast, in microsomal membranes of non-neoplastic breast tissue treated with these gangliosides, the methyltransferase activity was markedly increased. The addition of cholesterol to these microsomes led to complete inhibition of the GM1-stimulated enzyme activity. The methyltransferase activity was not affected by GM3 alone in either type of tissue. Experiments carried out on non-neoplastic microsomes revealed that the phospholipid methyltransferase-I was affected by that portion of gangliosides which remained stable associated to microsomal membranes.

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