PubMed · 7247828
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
R F Wetmore, R Scipione. 1981. Pathologic quiz case 2.. https://pubmed.ncbi.nlm.nih.gov/7247828/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Amphicrine carcinomas of the stomach, defined by dual exocrine and neuroendocrine differentiation within the same neoplastic cell, are exceedingly rare. MUTYH-associated polyposis (MAP) is an autosomal recessive polyposis syndrome characterized by multiple colorectal adenomas and variable upper gastrointestinal involvement; however, amphicrine carcinomas have not been previously documented in this setting. We report a gastric amphicrine carcinoma arising in the background of extensive fundic gland polyposis in a patient with MAP. Endoscopy revealed a 3.5-cm flat elevated lesion in the gastric fundus amid extensive fundic gland polyposis. Histologically, the tumor consisted of a single population of cells exhibiting combined glandular and neuroendocrine differentiation without zonal or biphasic architecture, and many of these cells demonstrated true amphicrine morphology. Immunohistochemistry confirmed co-expression of cytokeratin and the neuroendocrine markers chromogranin A and synaptophysin in the same cell population. Germline targeted next-generation sequencing identified biallelic MUTYH variants in trans (c.733C>T, p.Arg245Cys [likely pathogenic]; c.842C>T, p.Ala281Val [variant of uncertain significance]), supporting a diagnosis of MAP. To our knowledge, this is the first reported case of a gastric amphicrine carcinoma in a MAP patient, expanding the spectrum of MAP-associated upper gastrointestinal neoplasia and underscoring the importance of vigilant endoscopic surveillance in hereditary polyposis syndromes.
Explore the source record for details and available documents.
Human oncogenic viruses are heterogenous as a group but share the property of causing persistent and often lifelong infections. Immortalization of host cells is seen in some but not all infections. Chromosomal instability of the infected cells is probably important. Epidemiological data indicate that viral oncogenesis in humans is a multifactorial process where host factors such as age, race, sex and immune-competence, and exogenous factors such as coinfections and cocarcinogens, are important determinants.