Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain.

T Nabeshima; M Hiramatsu; M Amano; H Furukawa; T Kameyama

doi:10.1016/0014-2999(82)90325-9

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Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain.

T Nabeshima·M Hiramatsu·M Amano·H Furukawa·T Kameyama

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Abstract

The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalin in discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.

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Animals Brain Chemistry Depression, Chemical Enkephalin, Methionine Male Mice Mice, Inbred Strains Phencyclidine Time Factors Journal Article Research Support, Non-U.S. Gov't

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T Nabeshima, M Hiramatsu, M Amano, H Furukawa, T Kameyama. 1982-12-24. Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain.. https://doi.org/10.1016/0014-2999(82)90325-9

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