PubMed · 7097953
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G J Gilbert. 1982-08-27. Turtle headaches.. https://pubmed.ncbi.nlm.nih.gov/7097953/
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The neuroendocrine challenge paradigm provides a "window" on central neurotransmitter function in vivo. This strategy is based on the premise that the sensitivity of certain central receptors can be inferred from the magnitude of the hormonal response to specific pharmacologic probes. For example, the serotonin (5HT) receptor agonist m-chlorophenylpiperazine (m-CPP) stimulates the release of cortisol and prolactin and induces migraine-like headaches. We have previously reported that the headache and cortisol responses to m-CPP are highly correlated, which may implicate a disturbance in central serotonergic neurotransmission in the pathogenesis of migraine. As pharmacologic probes with greater specificity for 5HT receptor subtypes become available, we may be able to elucidate these mechanisms with greater precision. The neuroendocrine challenge methodology is also applicable to the study of other neurotransmitter systems and other headache disorders.
During the past year, several important papers have confirmed the association between psychological factors and headache. Recent studies are beginning to identify the specificity of the general association of headache subtypes with subtypes of psychiatric disorders and psychological traits. Studies of this topic have increasingly moved from the clinical arena to the community at large. Finally, much of the research on this topic is now driven by the goal of understanding the possible mechanisms for the concurrence of psychopathology and headache.