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PubMed · 681924

Hypothermic decrease in microtubule density and birefringence in unimyelinated axons.

D Rome-Talbot·D Andre·N Chalazonitis
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Abstract

The density of microtubules, T.D. (number of tubules/unit area) is highest in small crab nerve axons. After cooling of the nerve at 0 degrees C, the tubule density tends to zero (T.D. 2% of the normothermic value). Once the cooled nerves are returned in normothermia, the reconstitution of the microtubules is evidenced (T.D. = 90% of the initial normothermic value). Therefore cooling "depolymerizes" the tubules, whereas rewarming leads to their "repolymerization." These results definitely improve the interpretation of the birefringence decrease by cooling: as tubules and filaments contribute to the positive fraction of the total positive birefringence, their depolymerization by cooling explains to a large extent the decrease in total birefringence.

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AnimalsAxonsBirefringenceBrachyuraCold TemperatureMicrotubulesJournal Article

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D Rome-Talbot, D Andre, N Chalazonitis. 1978. Hypothermic decrease in microtubule density and birefringence in unimyelinated axons.. https://doi.org/10.1002/neu.480090402

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