Membrane attack by complement.

E R Podack; J Tschopp

doi:10.1016/0161-5890(84)90044-0

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PubMed · 6379417

Membrane attack by complement.

E R Podack·J Tschopp

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Abstract

Membrane attack by complement involves the self-assembly on membranes of five hydrophilic proteins (C5b, C6, C7, C8 and C9) to an amphiphilic tubular complex comprising approximately 20 subunits. The hydrophilic-amphiphilic transition of the precursor proteins is achieved by restricted unfolding and exposure of previously hidden hydrophobic domains. Restricted unfolding, in turn, is driven by high-affinity protein-protein interactions resulting in the formation of amphilic complexes. Circular polymerization of C9 to a tubular complex (poly C9) constitutes the molecular mechanism for transmembrane channel assembly and formation of ultrastructural membrane lesions.

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Animals Biopolymers Cell Membrane Chemical Phenomena Chemistry Complement Activation Complement C5 Complement C6 Complement C7 Complement C8 Complement C9 Complement Membrane Attack Complex Complement System Proteins Models, Chemical Protein Conformation Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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E R Podack, J Tschopp. 1984. Membrane attack by complement.. https://doi.org/10.1016/0161-5890(84)90044-0

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