Hypothalamic and preoptic area alpha 1-receptor concentrations decrease, and cerebral cortical alpha 1-receptor concentrations increase during postnatal maturation of male guinea pigs.

A E Johnson; B Nock; H Ryer; H Feder

doi:10.1159/000123898

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Hypothalamic and preoptic area alpha 1-receptor concentrations decrease, and cerebral cortical alpha 1-receptor concentrations increase during postnatal maturation of male guinea pigs.

A E Johnson·B Nock·H Ryer·H Feder

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Abstract

alpha 1-Receptors were measured in intact male guinea pigs during the course of postnatal development. Receptor concentrations were significantly higher at day 1 in hypothalamus and at days 1 and 14 in preoptic area than at day 60. Conversely, in cerebral cortex, receptor concentrations were significantly lower in neonatal animals than in 60-day-old animals. There was no change in affinity of the receptor during development. Castration has no apparent effect on alpha 1-receptor concentration in any brain area.

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Animals Animals, Newborn Brain Castration Cerebral Cortex Guinea Pigs Hypothalamus Male Prazosin Preoptic Area Receptors, Adrenergic, alpha Sexual Maturation Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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A E Johnson, B Nock, H Ryer, H Feder. 1984. Hypothalamic and preoptic area alpha 1-receptor concentrations decrease, and cerebral cortical alpha 1-receptor concentrations increase during postnatal maturation of male guinea pigs.. https://doi.org/10.1159/000123898

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