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Concomitant decrease in [3H]imipramine binding in cat brain and platelets after chronic treatment with imipramine.

M Briley·R Raisman·S Arbilla·M Casadamont·S Z Langer
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Abstract

Cats were treated chronically with imipramine (7.5 mg/kg i.p. twice daily for 20 days). Maximal [3H]dihydroalprenolol binding was reduced in the cerebral cortex of the treated animals whereas maximal [3H]spiroperidol binding to 5HT2-receptors was unchanged. Maximal [3H]imipramine binding was decreased to a similar extent in both hypothalamus and platelets of the same animals. This parallel decrease in [3H]imipramine binding in brain and platelets is discussed in relation to the lower [3H]imipramine binding found in platelets from untreated depressed patients as compared to those from control volunteers.

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AnimalsBinding SitesBlood PlateletsBrainCatsFemaleImipramineIn Vitro TechniquesMaleReceptors, Adrenergic, betaReceptors, SerotoninTritiumJournal Article

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M Briley, R Raisman, S Arbilla, M Casadamont, S Z Langer. 1982-07-09. Concomitant decrease in [3H]imipramine binding in cat brain and platelets after chronic treatment with imipramine.. https://doi.org/10.1016/0014-2999(82)90449-6

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