Search PubMed⌕ Search

Biomedical subjects

A D Ado

Publications and source records attributed to A D Ado.

At least 19 recordsLinked to original sources

[Nikolaĭ Nikalaevich Sirotinin and his school].

In a brief review of 50-year scientific activity of professor N. N. Sirotinin and his students the authors emphasize that this broad-minded scientist contributed to development of such disciplines as microbiology, pathophysiology, high-altitude, aerospace medicine. However, his main goal was evolution of reactivity and resistance, approaches to perfection of human health and performance. Much attention was paid to effects of low partial oxygen pressure on human and animal body, to hypoxic states of different origin. Methods of hypoxytherapy and hypoxic training are widely used in Russia and abroad. The contribution of academician N. N. Sirotinin to modern pathophysiology, high-altitude and aerospace physiology, internal and sport medicine is highly appreciated in Russia.

Aerospace Medicine↗

[Influence of "sessile"immune receptors of lymphocyte membranes on their cholinoreceptors in mice immunized with various antigens].

Influence of macromolecular agents (some agents) on cholinoreceptors' activity of lymphocytes' membranes and their ability to bind with acetylcholine and it's analogues (carbacholine and others) has been investigated. This work presents the materials to problem of receptors' interaction and express one of the immunopharmacological characteristics of "receptor-receptor" system.

Acetylcholine↗

[Role of lectins in allergic reactivity].

Skin reaction on phytohemagglutinin in healthy people and in patients with allergic bronchial asthma before and after specific hyposensitization has been studied. The attempt to determine interrelations between the skin sensitivity to phytohemagglutinin and some immunity indexes and to explain several links of lectins' action mechanisms during allergic processes have been made.

Adult↗

The responsiveness of mice B-lymphocytes to neuromediators during an immune reaction.

It was shown that increases of cAMP levels before and after adrenaline (10(-6) mol/liter) and cAMP levels before and after acetylcholine (10(-6) mol/liter) occur in mouse spleen B-lymphocytes in 2-3 and 3-6 days, respectively, after immunization with ovalbumin. Using radiolabeled blockers of these neuroreceptors, it was shown that their receptors on B-lymphocytes increase 3 and 3-4 days, respectively, after immunization. The data indicate that increases of spleen B-lymphocyte reactivity to neuromediators occur during an immune reaction associated, in part, with increases in the expression of their receptors.

Acetylcholine↗

[Effect of antiglobulin serum on the expression of M-cholinoreceptors of spleen lymphocytes of intact and immunized mice].

Using a labelled blocker of M-cholinoreceptors (M-CR)--3H-Quinuclidinyl benzilate--the number of the receptors on spleen lymphocytes has been determined before and after immunization of CBA and BALB/c mice with antiglobulin serum. The incubation of non-separated spleen cell suspension with antiglobulin serum decreased the number of M-CR by 14%, while the incubation of the enriched B-lymphocyte suspension decreased it by 32.5%. The immunization of animals with ovalbumin or bovine red blood cells increased the serum effect on M-CR expression in non-separated lymphocyte suspension and had practically no influence on the serum effect in B-lymphocyte suspension. Thus, the effect on immunoglobulin receptors of B lymphocytes has a pronounced influence on M-CR expression, which may be one of the mechanisms of nervous and immune systems interaction.

Animals↗

[M-cholinergic receptors of B-lymphocytes during immune response in mice].

The number of M-cholinergic receptors on spleen B-lymphocytes of CBA mice was determined using radioactive blocker 3H-Quinuclidinil benzilate. 3 and 4 days after the animals' immunization with ovalbumin the number of M-cholinergic receptors somewhat increased. Specific antigen attenuated M-cholinergic receptor expression on B-lymphocytes, most pronounced on day 4 after immunization, without affecting the receptor expression in control animals. Possible steric interaction between antigen-binding immunoglobulins and B-lymphocyte M-cholinergic receptors during immune response is suggested.

Animals↗