Search PubMed⌕ Search

PubMed · 612192

Toward classifying psychoactive chemical use.

Abstract

A classification scheme is proposed based on description of consequences of psychoactive chemical use. It is an alternative to current labels (e.g., alcoholic, drug abuser, chemically dependent) which are often controversial or pejorative, as well as being imprecise and limited to pathology. The categories are: Helpful, Low Risk Potential Harm, High Risk Potential Harm, and Harmful. These are briefly defined and illustrative examples are cited. The appropriate treatment responses for the four categories are, respectively: Encouragement, Accurate Information, Persuasive Education, and Active Intervention. The basic rationale and procedure for each is discussed. The system incorporates prevention as well as remediation.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J R Weinberg. 1977. Toward classifying psychoactive chemical use.. https://doi.org/10.3109/00952997709002749

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Occurrence and fate of barbiturates in the aquatic environment.

Barbiturates have been widely used as sedative hypnotics in the mid-1960s and since then mainly as veterinary drugs. To monitor their presence and fate in the aquatic environment, a method based on gas chromatography-mass spectrometry (GC-MS) has been developed to quantify butalbital, secobarbital, hexobarbital, aprobarbital, phenobarbital, and pentobarbital, all with a limit of detection (LOD) down to 1 ng/L. From the various investigated waste and surface water samples, barbiturates were only, but regularly detected in the Mulde, a tributary of the river Elbe in Germany at relevant concentrations up to several microg/L. Investigations of groundwater being affected with wastewater infiltration several decades ago also revealed a barbiturate pattern, indicating a strong recalcitrance of these drugs. To confirm this hypothesis, studies were carried out on biotic and abiotic degradation. Both, the biodegradability under aerobic conditions and hydrolysis did not show any degradation, implementing, that the investigated barbiturates, once released into the aquatic environment, show high stability over a long period of time.

Barbiturates↗

True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase.

A set of racemic N-alkylated barbiturates were investigated for their direct enantioselective HPLC separation on a new chiral stationary phase (CSP) containing cellulose tris(3,5-dimethylphenylcarabamate) immobilized onto silica gel (Chiralpak IB) and its coated version (Chiralcel OD). They were online detected by UV and optical rotation detectors to trace the elution order of their enantiomers. Surprisingly, examples of false and true reversal of the elution order of enantiomers of barbiturates were observed and reported.

Barbiturates↗