[Morphological restructurings in the brain due to a decrease in the catecholamine level].

V A Otellin; R P Kucherenko; E G Gilerovich; I P Usova; L A Fedosikhina

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PubMed · 6089476

[Morphological restructurings in the brain due to a decrease in the catecholamine level].

V A Otellin·R P Kucherenko·E G Gilerovich·I P Usova·L A Fedosikhina

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Abstract

Using light and electron microscopic examinations, the authors studied various portions of the rat brain following intracysternal administration of 6-hydroxydopamine. The lowered levels of noradrenaline in the cerebral tissue and an altered ultrastructure of neurons of the catecholaminergic centres and their processes were discovered in various areas of the brain. The time-course and the pattern of these readjustments may serve as a model for the investigation of the etiopathogenesis of various mental diseases and the elaboration of the methods of their pharmacotherapy.

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Animals Brain Catecholamines Dopamine Dose-Response Relationship, Drug Hydroxydopamines Microscopy, Electron Norepinephrine Oxidopamine Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Dopamine Time Factors Comparative Study English Abstract Journal Article

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V A Otellin, R P Kucherenko, E G Gilerovich, I P Usova, L A Fedosikhina. 1984. [Morphological restructurings in the brain due to a decrease in the catecholamine level].. https://pubmed.ncbi.nlm.nih.gov/6089476/

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