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PubMed · 575096

Enkephalin levels decrease in rat striatum during morphine abstinence.

L Bergström·L Terenius
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Abstract

Male Sprague-Dawley rats were treated with morphine for 11 days. Saline-injected animals served as controls. The striatal enkephalin levels were measured with a radioimmunoassay 2, 24 and 48 h after withdrawal. There was no change 2 h after the last morphine injection, but a marked reduction after 24 h and a slight decrease after 48 h. No decrease in enkephalin levels was found 12 and 24 h after a single dose of 20 mg/kg morphine.

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AnimalsAntibody FormationAntigen-Antibody ReactionsCorpus StriatumEndorphinsEnkephalinsHumansMaleMorphine DependenceRabbitsRatsSubstance Withdrawal SyndromeTime FactorsJournal Article

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L Bergström, L Terenius. 1979-12-20. Enkephalin levels decrease in rat striatum during morphine abstinence.. https://doi.org/10.1016/0014-2999(79)90240-1

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