PubMed · 466182
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R I Bayliss. 1979-06-23. Gout.. https://doi.org/10.1136/bmj.1.6179.1695
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The usual treatment of pericarditis consists of non-steroid anti-inflammatory agents. In cases where the symptoms and/or the pericardial effusion persist or progress, the disease can be arrested in the majority of cases by employing steroids. In some patients, it may prove difficult to conclude steroid treatment as gradual withdrawal results in recurrence and it may, therefore, be necessary to continue with large doses of steroid for prolonged periods. There is, however, a possibility for another form of treatment. The present authors present the case history of a patient with pericarditis on the basis of the post-myocardial-infarction syndrome and in whom the symptoms recurred several times during attempts at gradual withdrawal of prednisolone. Treatment with colchicine was commenced. The patient rapidly became symptom free and has now been symptom free for 45 weeks without prednisolone. Colchicine was withdrawn after 33 weeks without recurrence. It is considered that trial of colchicine treatment can be recommended in cases of recurring pericarditis particularly when there are problems (recurrence) on attempted withdrawal of steroid treatment. Naturally, it is important to exclude specific causes requiring other forms of treatment as the cause of the pericarditis (e.g. malignant disease, tuberculosis, systemic disease etc.).
Fluorescence spectra of several B-ring derivatives of allocolchicine in a variety of solvents have been obtained. The quantum yields of the allocolchicine derivatives decreased with amine substitution at the C-7 position [R = H greater than NH2 much greater than NHCH3 greater than N(CH3)2]. The relative fluorescent intensities of the aminoallocolchicinoids [R = NH2, NHCH3, N(CH3)2] bound to tubulin were significantly less than the fluorescent intensities of tubulin-bound allocolchicine (R = NHCOCH3) and deacetamidoallocolchicine (R = H). The low fluorescent intensities of the aminoallocolchicinoids in solvents and bound to tubulin could be explained by exciplex formation between the lone pair of electrons on the nitrogen and the allocolchicinoid pi-system, which leads to quenching of the allocolchicinoid fluorescence. Direct evidence for exciplex formation between the C-7 amine nitrogen and the allocolchicinoid pi-system was found in the emission spectrum of N-methyldemeallocolchicine [R = N(CH3)2] in dioxane. The quantum yields of the aminoallocolchicinoids in glycerol were higher than would be predicted on the basis of solvent dielectric effects. Glycerol appears to increase the quantum yields of the aminoallocolchicinoids through both viscosity and hydrogen-bonding effects. The latter effect serves to sequester the lone pair of electrons on the nitrogen, decreasing its ability to interact with the pi-system of the allocolchicinoid. It is concluded that the fluorescent properties of colchicinoids and allocolchicinoids in glycerol are not reliable indicators of the fluorescent properties of the molecules bound to tubulin.(ABSTRACT TRUNCATED AT 250 WORDS)
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