Haemochromatosis and the sicca syndrome.
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Hemochromatosis↗
Biomedical subjects
R I Bayliss
Publications and source records attributed to R I Bayliss.
Body weight and endocrine function in anorexia nervosa.
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Anorexia Nervosa↗
Idiopathic oedema of women. A clinical and investigative study.
A clinical and investigative study is reported of 19 patients with 'idiopathic oedema of women'. The resons for defining this as a specific syndrome unrelated to the menstrual cycle are given, and the clinical features reviewed. During a forced water diuresis the flow and composition of the urine and the plasma volume were studied on tilting from the supine to the upright position seven premenopausal and four postmenopausal patients with this disorder. No differences were found in the results obtained in the follicular and luteal phases of the menstrual cycle or in the pre- and post-menopausal patients. The reductions in urinary volume and electrolyte excretion on upright tilting were greater than those observed under similar circumstances during the luteal phase of the menstrual cycle in normal female controls, and attributed to increased proximal renal tubular reabsorption. The rate of loss of isotopically labelled albumin from the intravascular compartment was greater in patients with idiopathic oedema than in control subjects. A reduction in blood volume on tilting occurred in control subjects and patients with idiopathic oedema, but was greater in the latter; and the larger the fall, the greater were the reductions in urinary flow and electrolyte excretion. The effect of administering 9-alpha-fluorohydrocortisone was studied in nine patients with idiopathic oedema. One patient failed to 'escape' from the sodium-retaining action of this mineralocorticoid and developed pulmonary oedema; the others 'escaped' normally. The pathophysiological disturbance in this condition is related to increased loss of fluid from the vascular compartment but the precise aetiological mechanism remains unknown.
Adult↗
Postural fluid retention in patients with idiopathic oedema: lack of relationship to the phase of the menstrual cycle.
1. Water and electrolyte excretion was measured in the follicular and luteal phases of the menstrual cycle in seven patients with idiopathic oedema and in four post-menopausal patients with this condition. 2. In contrast to previous findings in healthy women, the reduction in urinary flow and sodium excretion on being tilted to the upright position was not significantly different in the follicular and luteal phases in pre-menopausal patients and there were no significant differences between pre- and post-menopausal patients. 3. The percentage increase in packed cell volume on standing was significantly greater in patients with idiopathic oedema than in normal subjects in the luteal phase of the menstrual cylcle. 4. It is postulated that the enhanced retention of electrolytes and water in response to tilting in patients with idiopathic oedema is a compensatory mechanism for the decreased effective blood volume at that time.
Adult↗