PubMed · 4489529
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J McGarry. 1973-07-20. Pre-eclampsia and eclampsia.. https://pubmed.ncbi.nlm.nih.gov/4489529/
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OBJECTIVE: To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population. DESIGN: A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups. SETTING: Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney. SUBJECTS: One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University. RESULTS: Genotypic and gene frequencies were not significantly different in the seven groups examined. CONCLUSION: There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype.
Perinatal losses have been studied in 37 pre-eclamptic/eclamptic patients: 13 of them exhibited a HELLP syndrome. Only 23 newborns survived (62.5%); after deduction of 4 pregnancies of less than 28 weeks, the perinatal mortality was 27%. Comparison with the local perinatal mortality showed a 6-fold higher risk for the fetus when pregnancy was complicated by pre-eclampsia/eclampsia, regardless of a superimposed HELLP syndrome. For reasons beyond our understanding the fetal losses with HELLP syndrome are much higher in primigravidae.