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PubMed · 42730991

Effect of self-activating phthalocyanine gel on palatal donor site healing, inflammatory biomarkers, somatosensory and patient-centered outcomes: a randomized split-mouth clinical trial.

Caique Andrade Santos·Rafael Sponchiado Cavallieri·Maria Carolina Sementille·Thiago José Dionísio·Rafaela Stocker Salbego·Carla Andreotti Damante·Leonardo Rigoldi Bonjardim·Mariana Schutzer Ragghianti Zangrando
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Abstract

OBJECTIVES: To evaluate effects of self-activating phthalocyanine (PHY) gel on palatal donor site after subepithelial connective tissue graft (SCTG) harvesting, considering clinical outcomes, inflammatory biomarkers, patient-centered outcomes, and quantitative somatosensory changes. MATERIALS AND METHODS: Twenty participants were included in this randomized, crossover, split-mouth clinical trial. Donor sites received topical PHY gel (PHY group-PHYG) and placebo gel (control group-CG). Clinical parameters (residual wound area-RWA, wound epithelialization-WE, residual remodeling area-RRA and tissue thickness-TM) were assessed at baseline, 7, 14, 30, and 60 days. Patient-centered outcomes were recorded during 14 postoperative days and inflammatory biomarkers at 3 and 7 days postoperatively. Mechanical detection threshold (MDT) and mechanical pain threshold (MPT) were evaluated at baseline, 2 months, and 6 months. RESULTS: PHYG and CG exhibited similar clinical outcomes, but PHYG demonstrated superior performance in reducing RRA. Both groups presented positive postoperative progression of patient-centered outcomes. IL-10 levels showed a significant increase in PHYG, suggesting a more favorable anti-inflammatory response. MDT remained stable but, donor sites exhibited transient hypersensitivity (MPT) at 2 months. CONCLUSIONS: PHYG and CG protocols promoted satisfactory healing of palatal donor sites. Most clinical parameters and patient-centered outcomes were similar between groups. The PHYG presented reduced RRA and increased IL-10 levels. Donor sites exhibited transient hypersensitivity, which tended to resolve over time. CLINICAL RELEVANCE: Both postoperative protocols resulted in favorable healing of palatal donor sites following SCTG harvesting, with comparable clinical and patient-centered outcomes. Quantitative sensory testing indicates that hypersensitivity may occur during healing, but sensory function tends to recover progressively.

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HumansFemaleWound HealingMaleBiomarkersGelsPalateIndolesAdultTreatment OutcomeIsoindolesCross-Over StudiesTransplant Donor SiteMiddle AgedConnective TissuePalatal donor sitePhthalocyanine derivativeQuantitative sensory testingRandomized clinical trialSubepithelial connective tissue graftWound healingJournal ArticleRandomized Controlled Trial

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Caique Andrade Santos, Rafael Sponchiado Cavallieri, Maria Carolina Sementille, Thiago José Dionísio, Rafaela Stocker Salbego, Carla Andreotti Damante, Leonardo Rigoldi Bonjardim, Mariana Schutzer Ragghianti Zangrando. 2026-09-12. Effect of self-activating phthalocyanine gel on palatal donor site healing, inflammatory biomarkers, somatosensory and patient-centered outcomes: a randomized split-mouth clinical trial.. https://doi.org/10.1007/s00784-026-07117-x

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Journal Article; Randomized Controlled Trial resourceAdult subjectBiomarkers subjectCross-Over Studies subjectFemale subjectHumans subjectJournal Article subjectMale subjectMiddle Aged subjectRandomized controlled trials study

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