Application of Perioperative Real-Time Fluorescence Imaging to Achieve High-Quality Debridement: A Randomized Control Trial.

Jui-Chen Hsu; Yi-Hung Chu; Yi-Chun Wu; Jung-Hsuan Chang; Ching-Uen Huang; Xin-Yi Lin; Yu-Fen Chiu; Fu-Yu Wang; Ka-Wai Tam; Shun-Cheng Chang

doi:10.1177/21621918251359558

PubMed · 40658376

Application of Perioperative Real-Time Fluorescence Imaging to Achieve High-Quality Debridement: A Randomized Control Trial.

Jui-Chen Hsu·Yi-Hung Chu·Yi-Chun Wu·Jung-Hsuan Chang·Ching-Uen Huang·Xin-Yi Lin·Yu-Fen Chiu·Fu-Yu Wang·Ka-Wai Tam·Shun-Cheng Chang

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Abstract

OBJECTIVE: To investigate the effectiveness of real-time fluorescence imaging (RTFI)-assisted debridement in managing chronic wounds compared with standard surgical debridement. APPROACH: This study was a patient-blinded, randomized clinical trial conducted from February 17, 2021, to July 30, 2021, on patients with chronic wounds. Patients were randomized to an RTFI group (M group) or conventional group (C group). The primary outcomes were as follows: percentage of residual bacterial area (preoperative and postoperative), number of debridements, high-quality debridement ratio, operation duration, and wound healing duration. RESULTS: A total of 100 patients were enrolled in both groups. No significant difference in the percentage of preoperative residual bacterial area or high-quality debridement ratio was seen. The M group underwent debridement an average of 2.6 times and had a significantly longer duration of operation (33.5 ± 12.7 min) than the C group (29.9 ± 10.4 min; p = 0.031). The postoperative residual bacterial area was significantly lower in the M than in the C group (6.83% ± 1.39% vs. 30.0% ± 12.37%, respectively; p < 0.001). The M group required significantly fewer wound healing days (49.2 ± 25.3 vs. 63.0 ± 27.9, p < 0.001). Secondary outcomes also demonstrated statistically significant differences in total hospitalized days (17.5 ± 9.3 vs. 21.5 ± 12.5, p < 0.01), days of antibiotic use (15.5 ± 8.7 vs. 18.7 ± 6.7, p < 0.01), and reinfection rates (4 of 100 vs. 22 of 100, p < 0.001). INNOVATION: RTFI can detect signals from normal skin components and bacterial metabolites. Therefore, interpretation of RTFI results should be correlated with the clinical condition. RTFI is associated with high-quality debridement. This technique can also be applied in targeted biopsy and in training young staff to mature debridement procedures. CONCLUSION: RTFI in debridement is associated with favorable clinical outcomes and may have a positive influence on chronic wound healing.

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Humans Debridement Female Male Wound Healing Middle Aged Optical Imaging Aged Chronic Disease Adult Treatment Outcome chronic wounds debridement fluorescence imaging wound healing Journal Article Randomized Controlled Trial

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Jui-Chen Hsu, Yi-Hung Chu, Yi-Chun Wu, Jung-Hsuan Chang, Ching-Uen Huang, Xin-Yi Lin, Yu-Fen Chiu, Fu-Yu Wang, Ka-Wai Tam, Shun-Cheng Chang. 2025-07-14. Application of Perioperative Real-Time Fluorescence Imaging to Achieve High-Quality Debridement: A Randomized Control Trial.. https://doi.org/10.1177/21621918251359558

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