Protective association of the ELMO1 rs741301 variant against diabetes mellitus and diabetic nephropathy: a systematic meta-analysis of case-control studies.

Sheena Mariam Thomas; Anu Shibi Anilkumar; Ramakrishnan Veerabathiran

doi:10.1080/03014460.2026.2723114

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Protective association of the ELMO1 rs741301 variant against diabetes mellitus and diabetic nephropathy: a systematic meta-analysis of case-control studies.

Sheena Mariam Thomas·Anu Shibi Anilkumar·Ramakrishnan Veerabathiran

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Abstract

CONTEXT: Diabetes mellitus (DM), an endocrine disorder, is characterised by persistently elevated blood glucose levels due to inadequate insulin production. Diabetic nephropathy (DN), is a critical complication associated with DM, often leading to end-stage renal failure and increased mortality. OBJECTIVE: This meta-analysis aimed to evaluate the association between the ELMO1 rs741301 polymorphism and susceptibility to DN among individuals with diabetes. METHOD: A systematic literature search was conducted for studies published between 2014 and 2024 using Embase, Google Scholar, and PubMed. Eligible case-control studies investigating the association between ELMO1 rs741301 and DN among individuals with DM were selected according to predefined inclusion criteria. Nine case-control studies comprising 880 individuals with DM and 1008 individuals with DN were included in the meta-analysis. RESULTS: The pooled analysis demonstrated a significant protective association between the ELMO1 rs741301 polymorphism and DN under the allelic model (OR = 0.77, 95% CI: 0.67-0.88), recessive model (OR = 0.74, 95% CI: 0.61-0.90), and dominant model (OR = 0.68, 95% CI: 0.53-0.88). In contrast, no statistically significant association was observed under the over-dominant model. CONCLUSION: The findings suggest that the ELMO1 rs741301 polymorphism may be associated with a reduced susceptibility to DN among individuals with DM. These findings provide evidence for a potential genetic contribution of ELMO1 to DN susceptibility and may help improve understanding of the genetic factors underlying diabetic complications. Further well-designed studies in diverse populations are warranted to validate this association.

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Humans Diabetic Nephropathies Adaptor Proteins, Signal Transducing Case-Control Studies Polymorphism, Single Nucleotide Genetic Predisposition to Disease Diabetes Mellitus Diabetes mellitus ELMO1 gene diabetic nephropathy genetic polymorphisms susceptibility Journal Article Meta-Analysis Systematic Review Review

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Sheena Mariam Thomas, Anu Shibi Anilkumar, Ramakrishnan Veerabathiran. 2026-09-02. Protective association of the ELMO1 rs741301 variant against diabetes mellitus and diabetic nephropathy: a systematic meta-analysis of case-control studies.. https://doi.org/10.1080/03014460.2026.2723114

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Adaptor Proteins, Signal Transducing subject Case-Control Studies subject Diabetes Mellitus subject Diabetic Nephropathies subject ELMO1 gene subject Genetic Predisposition to Disease subject Humans subject Journal Article subject Journal Article; Meta-Analysis; Systematic Review; Review resource Meta-Analysis subject Systematic reviews study diabetic nephropathy subject genetic polymorphisms subject

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