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Comparative evaluation of oxidative stress biomarkers F2-isoprostanes and 8-OHdG in Parkinson's disease and Type 2 Diabetes Mellitus: a systematic review and meta-analysis of human studies.

Samwel Sylvester Msigwa·Maiko Charles Mkwambe·Qiu-Yan Yu·Shi-Guo Zhu·Jian-Hong Zhu·Xiong Zhang·Jian-Yong Wang
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Abstract

BACKGROUND: Oxidative stress is central to type 2 diabetes mellitus (T2DM) and Parkinson's disease (PD). However, the utility of biomarkers for lipid peroxidation (F2-isoprostanes) and DNA damage (8-OHdG) in the comorbidity of PD and T2DM remains unclear. METHODS: We conducted a systematic review and meta-analysis of 54 unique studies of human subjects aged &#x2265; 50&#x2009;years (n&#x2009;=&#x2009;7,521: 3,522 with T2DM, 722 with PD, and 3,277 controls), measuring biomarkers in serum, plasma, or leukocytes. Mixed-effects models quantified standardized differences (Hedges' g) across subgroups. RESULTS: In T2DM, F2-isoprostanes (g&#x2009;=&#x2009;1.60, 95% CI: 0.95-2.25) and 8-OHdG (g&#x2009;=&#x2009;2.64, 95% CI: 2.13-3.14) were markedly elevated (p&#x2009;<&#x2009;0.001). Stronger effects were observed in younger cohorts and serum/plasma samples, with complications like nephropathy exhibiting extreme oxidative stress (g&#x2009;=&#x2009;5.24). In PD, 8-OHdG was moderately elevated (g&#x2009;=&#x2009;0.78, 95% CI: 0.18-1.39; p&#x2009;=&#x2009;0.011), particularly in randomized controlled trials and plasma samples, whereas F2-isoprostanes were not significantly elevated (g&#x2009;=&#x2009;0.47, 95% CI: -0.43-1.38). High heterogeneity in T2DM (I2 > 90%) reflected methodological variability. CONCLUSION: Distinct profiles - both markers elevated in T2DM but only 8-OHdG in PD - underscore 8-OHdG's potential in PD-T2DM comorbidity. Future research should focus on standardized assays, multi-compartmental or multi-modal sampling, and longitudinal studies to clarify mechanisms and therapeutic targets.

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HumansOxidative StressDiabetes Mellitus, Type 2F2-IsoprostanesBiomarkersParkinson Disease8-Hydroxy-2'-DeoxyguanosineDNA DamageLipid PeroxidationDeoxyguanosineMiddle Aged8-OHdGF2-isoprostanesOxidative stressParkinson&#x2019;s diseasecomorbiditydiabetesSystematic ReviewJournal ArticleMeta-AnalysisComparative StudyResearch Support, Non-U.S. Gov't

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Samwel Sylvester Msigwa, Maiko Charles Mkwambe, Qiu-Yan Yu, Shi-Guo Zhu, Jian-Hong Zhu, Xiong Zhang, Jian-Yong Wang. 2026-04-20. Comparative evaluation of oxidative stress biomarkers F2-isoprostanes and 8-OHdG in Parkinson's disease and Type 2 Diabetes Mellitus: a systematic review and meta-analysis of human studies.. https://doi.org/10.1080/07853890.2026.2654251

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8-Hydroxy-2'-Deoxyguanosine subject8-OHdG subjectBiomarkers subjectComorbidity subjectComparative Study subjectDNA Damage subjectDeoxyguanosine subjectDiabetes subjectDiabetes Mellitus, Type 2 subjectF2-Isoprostanes subjectHumans subjectJournal Article subjectLipid Peroxidation subjectMeta-Analysis subjectMiddle Aged subjectOxidative Stress subject

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