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PubMed · 42682010

Ribosomal protein S3: a critical regulator of human disease mechanisms.

Joeline Dreik·Marwa Al Ali·Jalil Daher·Zeina Nasr
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Abstract

Ribosomal protein S3 (RPS3) is an essential structural component of the 40S ribosomal subunit, yet growing evidence highlights crucial extraribosomal roles in genome maintenance, cell-cycle control, and immune signaling. Dysregulation of RPS3 contributes to diverse human disorders, including cancer, inflammatory diseases, neurodegeneration, and resistance to antimicrobial and anticancer therapies. As a cofactor of NF-κB and a participant in DNA damage responses, RPS3 occupies a node that integrates stress signaling with transcriptional reprogramming, enabling both protective and pathological outcomes. The present review critically evaluates mechanistic insights into RPS3 biology, emphasizing recent findings that delineate its context-dependent effects, discrepancies across models, and remaining gaps that restrict translational applications. Understanding these complexities is essential to assess RPS3's potential as a biomarker and therapeutic target.

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HumansRibosomal ProteinsSignal TransductionNeoplasmsAnimalsInflammationDNA DamageNF-kappa BDNA damage responseNF-κB signalingRPS3cancerinflammationribosomal stressJournal ArticleReview

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Joeline Dreik, Marwa Al Ali, Jalil Daher, Zeina Nasr. 2026-09-16. Ribosomal protein S3: a critical regulator of human disease mechanisms.. https://doi.org/10.1042/bsr20260051

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Journal Article; Review resourceAnimals subjectCancer subjectDNA Damage subjectHumans subjectJournal Article subjectNeoplasms subjectinflammation subject

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